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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKACB
All Species:
36.36
Human Site:
Y248
Identified Species:
72.73
UniProt:
P22694
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22694
NP_002722.1
351
40623
Y248
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
Chimpanzee
Pan troglodytes
XP_001136448
346
40126
Y243
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
Rhesus Macaque
Macaca mulatta
O62846
209
24077
S109
F
L
V
K
L
Q
F
S
F
K
D
N
S
N
L
Dog
Lupus familis
XP_867543
351
40605
Y248
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
Cat
Felis silvestris
Mouse
Mus musculus
P05132
351
40552
Y248
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
Rat
Rattus norvegicus
P68182
351
40689
Y248
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q6U1I9
432
48872
Y307
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
Frog
Xenopus laevis
Q6GPN6
434
49096
Y309
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
Zebra Danio
Brachydanio rerio
Q7ZTW4
433
48964
A305
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12370
353
40820
Y250
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P21137
404
46327
Y285
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06245
380
44201
Y274
D
T
T
P
M
K
T
Y
E
K
I
L
Q
G
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.1
47.8
98.8
N.A.
92
96.8
N.A.
N.A.
35.6
35.2
34.4
N.A.
82.1
N.A.
66.3
N.A.
Protein Similarity:
100
98
54.1
99.1
N.A.
95.1
98
N.A.
N.A.
54.6
55
54.2
N.A.
89.8
N.A.
77.4
N.A.
P-Site Identity:
100
100
20
100
N.A.
100
100
N.A.
N.A.
13.3
13.3
6.6
N.A.
100
N.A.
100
N.A.
P-Site Similarity:
100
100
26.6
100
N.A.
100
100
N.A.
N.A.
53.3
53.3
13.3
N.A.
100
N.A.
100
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
46.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
65.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
59
0
0
0
17
0
0
9
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
59
0
0
0
0
0
0
17
0
9
9
0
0
0
% D
% Glu:
0
0
0
0
0
17
0
0
75
0
0
0
0
0
0
% E
% Phe:
9
9
0
0
0
0
9
0
9
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
59
0
59
0
0
0
84
0
0
9
0
% I
% Lys:
0
0
0
9
0
9
0
0
0
75
0
0
0
17
67
% K
% Leu:
0
9
0
0
9
0
0
0
0
0
0
25
0
0
17
% L
% Met:
0
0
0
0
9
0
17
0
0
9
0
0
0
0
0
% M
% Asn:
0
0
17
0
0
9
0
0
0
17
0
9
25
9
0
% N
% Pro:
9
0
0
67
0
0
0
0
0
0
0
0
0
0
17
% P
% Gln:
0
0
59
0
0
67
0
0
0
0
0
0
9
0
0
% Q
% Arg:
0
17
0
0
9
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
17
0
0
9
0
0
0
9
0
0
0
0
67
0
0
% S
% Thr:
0
9
9
17
0
0
17
0
0
0
0
0
0
0
0
% T
% Val:
0
0
9
0
0
0
0
0
0
0
0
59
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
84
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _